MovDisordV3, Main, Exploration, bibRecord, 000793

Results of the Citalopram to Enhance Cognition in Huntington Disease Trial

Identifieur interne : 000793 ( Main/Exploration ); précédent : 000792; suivant : 000794

Results of the Citalopram to Enhance Cognition in Huntington Disease Trial

Auteurs : Leigh J. Beglinger [États-Unis] ; William H. Adams [États-Unis] ; Douglas Langbehn [États-Unis] ; Jess G. Fiedorowicz [États-Unis] ; Ricardo Jorge [États-Unis] ; Kevin Biglan [États-Unis] ; John Caviness [États-Unis] ; Blair Olson [États-Unis] ; Robert G. Robinson [États-Unis] ; Karl Kieburtz [États-Unis] ; Jane S. Paulsen [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.

RBID : PMC:3960314

English descriptors

KwdEn :
- Adult, Aged, Citalopram (therapeutic use), Cognition (drug effects), Depressive Disorder (etiology), Depressive Disorder (psychology), Double-Blind Method, Drug Administration Schedule, Executive Function (drug effects), Female, Humans, Huntington Disease (complications), Huntington Disease (drug therapy), Huntington Disease (psychology), Male, Middle Aged, Treatment Outcome, Young Adult.
MESH :
- chemical , therapeutic use : Citalopram.
- complications : Huntington Disease.
- drug effects : Cognition, Executive Function.
- drug therapy : Huntington Disease.
- etiology : Depressive Disorder.
- psychology : Depressive Disorder, Huntington Disease.
- Adult, Aged, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Treatment Outcome, Young Adult.

Abstract

Objective

Evaluate citalopram for executive functioning in HD.

Design

Randomized, double-blind, placebo-controlled.

Patients

Thirty-three adults with HD, cognitive complaints and no depression (Hamilton Depression Rating Scale ≤12).

Intervention

Citalopram 20 mg or placebo [7 visits, 20 weeks], with practice and placebo run-ins.

Primary Outcome

Change in executive functioning.

Results

Intent to treat analysis controlling for practice effects comparing visits 1–2 to 5–6 for citalopram vs. placebo. There were no significant benefits on the executive function composite (treatment-placebo mean difference −0.167 95% CI (−0.361 to 0.028), p=.092). Citalopram participants showed improved clinician-rated depression symptoms on the HAM-D (t=−2.02, p=0.05). There were no group differences on motor ratings, self-reported executive functions, psychiatric symptoms or functional status.

Conclusion

No evidence that short-term treatment with citalopram improved executive functions in HD. Despite excluding patients with active depression, participants on citalopram showed improved mood, raising the possibility of efficacy for subsyndromal depression in HD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960314

DOI: 10.1002/mds.25750
PubMed: 24375941
PubMed Central: 3960314

Affiliations:

Le document en format XML

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<author><name sortKey="Jorge, Ricardo" sort="Jorge, Ricardo" uniqKey="Jorge R" first="Ricardo" last="Jorge">Ricardo Jorge</name>
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<author><name sortKey="Caviness, John" sort="Caviness, John" uniqKey="Caviness J" first="John" last="Caviness">John Caviness</name>
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<author><name sortKey="Olson, Blair" sort="Olson, Blair" uniqKey="Olson B" first="Blair" last="Olson">Blair Olson</name>
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<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
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<author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Results of the Citalopram to Enhance Cognition in Huntington Disease Trial</title>
<author><name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh J." last="Beglinger">Leigh J. Beglinger</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
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<placeName><region type="state">Idaho</region>
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<author><name sortKey="Adams, William H" sort="Adams, William H" uniqKey="Adams W" first="William H." last="Adams">William H. Adams</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Loyola University Chicago, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Loyola University Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
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<author><name sortKey="Langbehn, Douglas" sort="Langbehn, Douglas" uniqKey="Langbehn D" first="Douglas" last="Langbehn">Douglas Langbehn</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
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<author><name sortKey="Fiedorowicz, Jess G" sort="Fiedorowicz, Jess G" uniqKey="Fiedorowicz J" first="Jess G." last="Fiedorowicz">Jess G. Fiedorowicz</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Jorge, Ricardo" sort="Jorge, Ricardo" uniqKey="Jorge R" first="Ricardo" last="Jorge">Ricardo Jorge</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Biglan, Kevin" sort="Biglan, Kevin" uniqKey="Biglan K" first="Kevin" last="Biglan">Kevin Biglan</name>
<affiliation wicri:level="2"><nlm:aff id="A4">University of Rochester, Rochester, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, Rochester, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caviness, John" sort="Caviness, John" uniqKey="Caviness J" first="John" last="Caviness">John Caviness</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Mayo Clinic Scottsdale, Scottsdale, AZ, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mayo Clinic Scottsdale, Scottsdale, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olson, Blair" sort="Olson, Blair" uniqKey="Olson B" first="Blair" last="Olson">Blair Olson</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Robinson, Robert G" sort="Robinson, Robert G" uniqKey="Robinson R" first="Robert G." last="Robinson">Robert G. Robinson</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
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<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<affiliation wicri:level="2"><nlm:aff id="A4">University of Rochester, Rochester, NY, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Rochester, Rochester, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
<affiliation wicri:level="4"><nlm:aff id="A1">University of Iowa, Iowa City, IA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Iowa City, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2013">2013</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Citalopram (therapeutic use)</term>
<term>Cognition (drug effects)</term>
<term>Depressive Disorder (etiology)</term>
<term>Depressive Disorder (psychology)</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Executive Function (drug effects)</term>
<term>Female</term>
<term>Humans</term>
<term>Huntington Disease (complications)</term>
<term>Huntington Disease (drug therapy)</term>
<term>Huntington Disease (psychology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Citalopram</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cognition</term>
<term>Executive Function</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depressive Disorder</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depressive Disorder</term>
<term>Huntington Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
<term>Young Adult</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">Evaluate citalopram for executive functioning in HD.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Randomized, double-blind, placebo-controlled.</p>
</sec>
<sec id="S3"><title>Patients</title>
<p id="P3">Thirty-three adults with HD, cognitive complaints and no depression (Hamilton Depression Rating Scale ≤12).</p>
</sec>
<sec id="S4"><title>Intervention</title>
<p id="P4">Citalopram 20 mg or placebo [7 visits, 20 weeks], with practice and placebo run-ins.</p>
</sec>
<sec id="S5"><title>Primary Outcome</title>
<p id="P5">Change in executive functioning.</p>
</sec>
<sec id="S6"><title>Results</title>
<p id="P6">Intent to treat analysis controlling for practice effects comparing visits 1–2 to 5–6 for citalopram vs. placebo. There were no significant benefits on the executive function composite (treatment-placebo mean difference −0.167 95% CI (−0.361 to 0.028), <italic>p</italic>
=.092). Citalopram participants showed improved clinician-rated depression symptoms on the HAM-D (t=−2.02, <italic>p</italic>
=0.05). There were no group differences on motor ratings, self-reported executive functions, psychiatric symptoms or functional status.</p>
</sec>
<sec id="S7"><title>Conclusion</title>
<p id="P7">No evidence that short-term treatment with citalopram improved executive functions in HD. Despite excluding patients with active depression, participants on citalopram showed improved mood, raising the possibility of efficacy for subsyndromal depression in HD.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Idaho</li>
<li>Illinois</li>
<li>Iowa</li>
<li>État de New York</li>
</region>
<settlement><li>Iowa City</li>
</settlement>
<orgName><li>Université de l'Iowa</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Iowa"><name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh J." last="Beglinger">Leigh J. Beglinger</name>
</region>
<name sortKey="Adams, William H" sort="Adams, William H" uniqKey="Adams W" first="William H." last="Adams">William H. Adams</name>
<name sortKey="Beglinger, Leigh J" sort="Beglinger, Leigh J" uniqKey="Beglinger L" first="Leigh J." last="Beglinger">Leigh J. Beglinger</name>
<name sortKey="Biglan, Kevin" sort="Biglan, Kevin" uniqKey="Biglan K" first="Kevin" last="Biglan">Kevin Biglan</name>
<name sortKey="Caviness, John" sort="Caviness, John" uniqKey="Caviness J" first="John" last="Caviness">John Caviness</name>
<name sortKey="Fiedorowicz, Jess G" sort="Fiedorowicz, Jess G" uniqKey="Fiedorowicz J" first="Jess G." last="Fiedorowicz">Jess G. Fiedorowicz</name>
<name sortKey="Jorge, Ricardo" sort="Jorge, Ricardo" uniqKey="Jorge R" first="Ricardo" last="Jorge">Ricardo Jorge</name>
<name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
<name sortKey="Langbehn, Douglas" sort="Langbehn, Douglas" uniqKey="Langbehn D" first="Douglas" last="Langbehn">Douglas Langbehn</name>
<name sortKey="Olson, Blair" sort="Olson, Blair" uniqKey="Olson B" first="Blair" last="Olson">Blair Olson</name>
<name sortKey="Paulsen, Jane S" sort="Paulsen, Jane S" uniqKey="Paulsen J" first="Jane S." last="Paulsen">Jane S. Paulsen</name>
<name sortKey="Robinson, Robert G" sort="Robinson, Robert G" uniqKey="Robinson R" first="Robert G." last="Robinson">Robert G. Robinson</name>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Results of the Citalopram to Enhance Cognition in Huntington Disease Trial

Results of the Citalopram to Enhance Cognition in Huntington Disease Trial

Source :

English descriptors

Abstract

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	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.